If treatment-related toxicities might influence compliance or adherence, a change to another endocrine treatment option is highly recommended to avoid treatment discontinuation in the adjuvant setting. Also, by giving chemo before the neoplasm is removed, doctors will higher see however the cancer responds to that. Breast Cancer Clinical Trials: Table 2 Superiority of carboplatin-contain-ing regimens in the neoadjuvant setting [ 1 ]. Current Research Hereditary Genetics: Gallen panelists regard lymphovascular tumor invasion as a sole indication for adjuvant chemotherapy. Ando M et al.